Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis
March 2018
in “
The Journal of Clinical Endocrinology & Metabolism
”
Studysummary This study reported that estrogen-progestin oral contraceptives, antiandrogens, and insulin sensitizers are more effective than placebo in treating hirsutism in women, with combination therapies generally proving superior to monotherapy.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The systematic review and network meta-analysis conducted by the Mayo Clinic evaluated 43 randomized controlled trials to assess treatment options for hirsutism in women. The study found that estrogen-progestin oral contraceptive pills (OCPs), antiandrogens, and insulin sensitizers were more effective than placebo, with antiandrogens showing the greatest efficacy. Combinations of OCPs with antiandrogens or insulin sensitizers were more effective than monotherapy. Individual antiandrogens like flutamide, finasteride, and spironolactone were effective and comparable. The study highlighted moderate certainty in comparisons with placebo but low certainty in head-to-head comparisons due to methodological limitations. The analysis suggested OCPs as first-line therapy, especially when contraception is needed, and noted the teratogenic potential of antiandrogens.
