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research Upregulation of mir-1199-5p is associated with reduced type 2 5-α reductase expression in benign prostatic hyperplasia

6 citations , November 2022 in “BMC Urology”

In this study, researchers found that the microRNA miR-1199-5p may reduce the expression of SRD5A2 in benign prostatic hyperplasia tissues, potentially contributing to the failure of 5-α reductase inhibitor therapy in some patients.

research Risk of Type 2 Diabetes Mellitus in New Users of 5-Alpha Reductase Inhibitors: A Nationwide Historical Cohort Study

January 2026 in “Yonsei Medical Journal”

Finasteride and dutasteride have little effect on Type 2 Diabetes risk.

research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations , July 2016 in “Urologic Clinics of North America”

This study found that combining 5-alpha reductase inhibitors with alpha-blockers provided the best symptomatic relief and reduced the risk of clinical progression for BPH, while PDE5 inhibitors could offset sexual side effects.

research Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs

15 citations , November 2015 in “Pharmacopsychiatry”

This review discusses sexual dysfunction as a side effect of α-blockers and 5-ARIs for BPH/LUTS, highlighting methodological flaws in existing studies and the need for more rigorous research.

research Sponsored Lecture 3 : Updates on 5 alpha-rers(5ARIs) for the treatment of male pattern hair loss(MPHL)

January 2014 in “프로그램북(구 초록집)”

This article reviews updates on 5 alpha-reductase inhibitors for treating male pattern hair loss and presents no new clinical findings; the author aims to enhance understanding of these therapies.

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community 5ARi of choice not working yet? Paper Review for efficacy + safety

in Research/Science 14 upvotes 7 months ago

Dutasteride is more effective than finasteride for hair loss, especially at the crown and midscalp, but both have similar side-effect profiles with low incidence of sexual adverse events. Improvement is measured visually, and significant results may take over 12 months to appear.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community How do you keep your bloodsugar low on finasteride?

12 upvotes 2 years ago

Finasteride may affect blood sugar and metabolism, with some users reporting increased blood sugar and changes in body composition. To manage potential side effects, users suggest exercise, intermittent fasting, and dietary adjustments.

community 4 years on meds. From balding to fin and from fin to dut.

in Progress Pictures 52 upvotes 10 months ago

The user switched from finasteride to dutasteride and oral minoxidil after experiencing side effects and worsening hair loss, which improved their condition. Dutasteride was preferred due to fewer side effects and better results compared to finasteride.

community Dutasteride likely reduces Bone Mineral Density

in Research/Science 5 months ago

Dutasteride may reduce bone mineral density, but there's no increased risk of osteoporosis or fractures compared to finasteride. Users suggest resistance training to counter potential bone effects.

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learn Hair Transplant

How do I know which hair restoration treatment is right for me? Consult a professional for a personalized hair restoration treatment plan based on your needs.
What results can I expect from a hair transplant? Expect new hair growth in 3-4 months, with full results in 9-12 months.
When can I cut or style my hair after a hair transplant? You can cut or style your hair about 1 month after a hair transplant.
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learn Scalp Micropigmentation

How soon can I exercise after scalp micropigmentation? Avoid heavy exercise for 4-10 days after scalp micropigmentation to ensure proper healing.

learn Overview

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