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Glossary Suicidality

Suicidality refers to the spectrum of thoughts, behaviors, and actions related to self-harm or the desire to end one's life. In the context of hair loss, individuals experiencing significant hair thinning or baldness may face emotional distress, leading to feelings of hopelessness or depression, which can increase the risk of suicidality. Understanding this connection is crucial for providing appropriate mental health support to those affected by hair loss, as it highlights the psychological impact that physical appearance can have on overall well-being. Key distinguishing characteristics include the presence of suicidal ideation, plans, or attempts, which necessitate immediate intervention and care.

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research Signal detection between 5-alpha reductase inhibitors and the risk of suicidality and depression: an international pharmacovigilance analysis

1 citations , June 2025 in “European Journal of Clinical Pharmacology”

In this study, researchers found a statistically significant increase in reports of suicidality and depression associated with finasteride use, especially in younger individuals, whereas dutasteride showed no significant signal for suicidality and a weaker signal for depression.

research Association of Hair Loss With Suicidality and Psychological Adverse Events vs Finasteride Use—Reply

1 citations , May 2021 in “JAMA Dermatology”

This abstract is a website layout text and does not include any research findings or study results.

research Suicidality and Psychological Adverse Events in Patients Treated with Finasteride

1 citations , January 2021 in “Skin appendage disorders”

research (719) Signal Detection of Depression and Suicidality With the 5-Alpha Reductase Inhibitors: Evidence from the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) Database

June 2026 in “The Journal of Sexual Medicine”

This study found that psychiatric adverse drug reactions were more frequently reported with finasteride than with dutasteride, but it remains unclear if there is a causal relationship.

research Signal Detection of Depression and Suicidality Associated with Finasteride and Dutasteride: Updated Pharmacovigilance Evidence and Recommendations for Comprehensive Psychiatric Assessment

April 2026 in “Brain Sciences”

This pharmacovigilance study analyzed FAERS data and found that finasteride is more frequently associated with neuropsychiatric reactions like depression and suicide risk, especially in younger men using it for alopecia, compared to dutasteride.

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