(7E)-7,8-Dehydroheliobuphthalmin From Platycladus Orientalis L.: Isolation, Characterization, And Hair Growth Promotion
May 2025
in “
International Journal of Molecular Sciences
”
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Studysummary In a mouse study, Fr2 from Platycladus orientalis L. significantly enhanced hair growth, suggesting its potential as a natural therapeutic agent for hair regeneration.
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The study explores the hair growth-promoting effects of (7E)-7,8-Dehydroheliobuphthalmin (DHHB) isolated from Platycladus orientalis L. In vivo tests on androgenetic alopecia (AGA) mouse models and in vitro experiments with dermal papilla cells (DPCs) revealed that DHHB significantly enhances hair growth by increasing hair follicle density, improving antioxidant enzyme activities, and reducing oxidative stress markers. DHHB also modulates the Wnt/β-catenin signaling pathway and suppresses TGF-β mRNA expression, crucial for hair growth regulation. These findings suggest DHHB as a promising natural alternative to conventional hair growth treatments, warranting further investigation into its therapeutic efficacy.
