Hyaluronic Acid Microneedles Loaded with Chinese Herbal Extracts as an Intradermal Delivery System for Hair Regeneration

April 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Jiaquan Hong (21080696), Bocheng Xu (9958538), Xiaole Hu (3335241), Chun Liu (47227), Hongsheng Liu (1729933), Jinhuan Tian (8740749), Lihua Li (1408309), Shan Ding (3446876), Changren Zhou (1723939), Lu Lu (392)

hyaluronic acid microneedles Platycladus orientalis leaf extract intradermal delivery system androgenic alopecia HAMA/HA hydrogel hair follicle cell proliferation reactive oxygen free radicals Wnt/β-catenin pathway PO-ex MN hair regeneration hair growth

TLDR Hyaluronic acid microneedles with herbal extracts may effectively promote hair growth for treating hair loss.

The study explores the use of hyaluronic acid microneedles (PO-ex MN) loaded with Platycladus orientalis leaf extract as a novel intradermal delivery system for hair regeneration in treating androgenic alopecia. The microneedles, made from a double cross-linked HAMA/HA hydrogel, effectively penetrate the skin to deliver the extract into the dermis. This delivery system enhances hair follicle cell proliferation by removing reactive oxygen free radicals and activates the Wnt/β-catenin pathway through mechanical stimulation, promoting hair growth. The findings suggest that PO-ex MN could be a promising therapeutic strategy for androgenic alopecia.

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