Performance of Platycladus Orientalis Leaves Yeast Fermented Solution on Human Dermal Papilla Cells

January 2026 in “ Cosmetics ”

K. W. Chang, Lingjuan Liu, Xianqi Chen, Yuan Li, Timson Chen, Zhizhen Li, Ya Chen, Ling Ma, Jing Wang

Platycladus orientalis yeast-fermented solution human dermal papilla cells HDPCs VEGF TGF-β1 IL-6 hair follicle cell proliferation minoxidil Rogaine

From the encyclopedia

platycladus orientalis →

Vascular Endothelial Growth Factor →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary In this study, yeast fermentation of Platycladus orientalis leaves was shown to enhance hair growth-promoting properties by affecting cell cycle phases in human dermal papilla cells, increasing growth factor VEGF, reducing inflammatory factor TGF-β1, and altering the expression of Wnt/β-catenin pathway-related genes.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explores the effects of a yeast-fermented solution made from Platycladus orientalis leaves on human dermal papilla cells (HDPCs), which are vital for hair growth. The research shows that the fermented solution significantly enhances HDPC proliferation, with a 152.45% increase at 2.5 mg/mL, and modulates key signaling pathways, including upregulation of VEGF and downregulation of TGF-β1 and IL-6. These changes suggest improved hair follicle cell proliferation and reduced inflammation, comparable to traditional treatments like minoxidil. The study highlights the potential of this natural product as a safer alternative for hair loss treatment, though further validation in animal models is needed due to the limitation of using HDPC monocultures.

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