ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway

The study explores the effects of ICP5249 on hair growth, demonstrating that it promotes hair growth by activating the AMPK-autophagy signaling pathway. ICP5249 enhances the proliferation of human dermal papilla cells (hDPCs) and increases hair shaft growth in human hair follicles (hHFs). In C57BL/6 mice, ICP5249 treatment led to increased hair growth and dermis thickness, which was inhibited by the AMPKα inhibitor, compound C, confirming the role of AMPKα in this process. These findings suggest that ICP5249 could be a promising therapeutic approach for hair loss disorders by modulating autophagy, although further research is needed to assess its effectiveness in treating alopecia.