Hair Growth-Promoting Effect of Human Dermal Stem/Progenitor Cell-Derived Conditioned Medium

August 2015 in “ Tissue Engineering and Regenerative Medicine ”

Ji Sung Shim

human dermal stem/progenitor cell-derived conditioned medium hDSPC-CM alkaline phosphatase ALP dermal papilla cell markers Wnt3a protein Wnt/ß-catenin pathway hair regeneration C57BL/6 mice stem cell-derived conditioned medium Wnt protein hair growth pathway

TLDR Human skin cell byproducts can potentially be used to treat hair loss and promote hair growth.

Eight years ago, a study found that human dermal stem/progenitor cell-derived conditioned medium (hDSPC-CM) could potentially be used as a treatment for hair loss. The research showed that hDSPC-CM increased alkaline phosphatase (ALP) activity and the expression of certain dermal papilla cell markers. It also significantly increased the secretion of Wnt3a protein, which was found to restore ALP activity. The study further explored the effect of hDSPC-CM on hair regeneration in C57BL/6 mice, highlighting the connection between the Wnt/ß-catenin pathway and hair formation.

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