Effect of Conditioned Media Collected from Human Amniotic Fluid-Derived Stem Cells on Skin Regeneration and Photo-Aging

In 2014, researchers studied the impact of conditioned media from human amniotic fluid-derived stem cells (hAFSC-CM) on skin regeneration and photo-aging. They discovered that hAFSC-CM significantly promoted cell proliferation in dermal fibroblasts by 132.72 ± 7.48% and in skin epidermal cells by 125.95 ± 4.61%. The media also enhanced wound healing in vitro and showed a protective effect against UVA-induced damage by down-regulating MMP-1, an enzyme that degrades collagen, and up-regulating procollagen 1A expression. These findings indicate that hAFSC-CM could potentially aid in skin regeneration and counteract the effects of photo-aging. The study did not specify the number of samples or participants involved. Further research was suggested to refine UVA irradiation methods and analyze the roles of growth factors and cytokines in hAFSC-CM. The research received support from the Korea Healthcare technology R&D Project and the National Research Foundation of Korea.