The Role of Lipids in Promoting Hair Growth Through HIF-1 Signaling Pathway

    February 2025 in “ Scientific Reports ”
    Jieun Seo, Kinzo Matsumoto, Ayaka Nanmo, Shan Tung Tu, Do-Won Jeong, Yang‐Sook Chun, Lei Yan, Tatsuto Kageyama, Junji Fukuda
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    TLDR Lipids may help treat hair loss by promoting hair growth.
    This study investigates the role of lipids in hair growth, particularly through the HIF-1 signaling pathway. Researchers observed reduced lipid metabolism in the scalp tissues of patients with androgenetic alopecia. Supplementing lipids in culture mediums enhanced hair growth-related gene expression and the proliferation of human dermal papilla cells (DPCs). RNA-sequencing and HIF-1α knockdown experiments identified HIF-1α as a key regulator in lipid-induced upregulation of trichogenic genes. Additionally, in vitro tests with hair follicle organoids showed that lipids promoted the elongation of hair-shaft-like structures. These findings suggest that targeting lipid pathways could be a promising strategy for treating hair loss.
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