Effects of Oxytocin Receptor Agonists on Hair Growth Promotion

October 2024 in “ Scientific Reports ”

Tatsuto Kageyama, Jieun Seo, Lei Yan, Junji Fukuda

oxytocin receptor agonists LIT001 WAY267464 alopecia hair growth dermal papilla cells hair follicloids oxytocin OXTR RNA-based therapies hair loss hair growth promotion

Studysummary This research observed that oxytocin receptor agonists WAY267464 and LIT001 increased hair growth-related gene expression in human dermal papilla cells and significantly promoted hair follicle sprouting in vitro, suggesting their potential as hair growth agents targeting OXTR for alopecia treatment. Our plain-language summary of this paper — not a Tressless recommendation.

This study explores the use of oxytocin receptor (OXTR) agonists, LIT001 and WAY267464, as potential treatments for alopecia by promoting hair growth. These agonists were found to upregulate hair growth-related genes in dermal papilla cells and enhance hair shaft elongation in hair follicloids. The study addresses the limitations of oxytocin, such as its short half-life and low receptor specificity, which can cause side effects. LIT001 and WAY267464, with their lower molecular weights, may overcome these issues. Bioinformatic analysis suggests that low OXTR expression in dermal papilla cells is linked to hair loss, indicating OXTR as a promising therapeutic target. The study proposes that OXTR agonists could be effective alternatives to oxytocin, potentially offering additional benefits when combined with other treatments. Further research is needed to understand the mechanisms of these agonists and their effects on hair growth, as well as the potential of RNA-based therapies to enhance OXTR expression.

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16 / 16 results

research Effects of Oxytocin on the Hair Growth Ability of Dermal Papilla Cells

October 2023 in “Scientific Reports”

This study explored the effects of oxytocin on hair growth and found that it upregulated growth-promoting factors in dermal papilla cells and hair follicle organoids, suggesting potential for developing new alopecia treatments.

research Clinical Outcomes for Uptitration of Baricitinib Therapy in Patients With Severe Alopecia Areata

1 citations , August 2023 in “JAMA Dermatology”

In this study, baricitinib 4 mg led to greater scalp, eyebrow, and eyelash hair regrowth in severe alopecia areata patients than baricitinib 2 mg at weeks 36 and 52.

research Janus Kinase Inhibitors For Alopecia Areata

12 citations , June 2023 in “JAMA network open”

In this study of seven randomized clinical trials, JAK inhibitors were associated with improved hair regrowth outcomes in alopecia areata patients compared to placebo, with oral administration being more effective than external application, though longer trials are needed to confirm safety and effectiveness.

research In Vitro Hair Follicle Growth Model for Drug Testing

3 citations , March 2023 in “Scientific Reports”

This study found that organoid cultures of human epithelial and mesenchymal cells can produce hair peg-like structures, and their growth is enhanced by minoxidil, suggesting potential for hair drug screening.

research Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia

November 2022 in “Molecular Pharmaceutics”

This study found that intradermal injection of a cell-penetrating, AR-targeting asiRNA promoted hair growth and reduced androgen receptor expression in mouse models of androgenetic alopecia, suggesting its therapeutic potential.

research Impacts of Manipulating Cell Sorting on In Vitro Hair Follicle Regeneration

1 citations , October 2022 in “Journal of Bioscience and Bioengineering”

This study found that Y27632 treatment facilitated the formation of core-shell-shaped hair follicle organoids, resulting in nearly 100% efficient hair shaft sprouting in vitro.

research Co-Delivery of Bioactive Peptides by Nanoliposomes for Promotion of Hair Growth

4 citations , May 2022 in “Journal of Drug Delivery Science and Technology”

This research observed that nanoliposomes delivering a combination of bioactive peptides significantly promoted hair growth in vitro and in vivo by enhancing the proliferation and function of hair growth-targeted cells in C57BL/6 mice, suggesting a promising approach for treating androgenetic alopecia.

research Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia

3 citations , January 2022 in “Scientific Reports”

This study found that SAMiRNA-AR68, a nanomedicine targeting androgen receptor mRNA, increased hair counts in androgenetic alopecia patients with no observed side effects.

research Finasteride for Hair Loss: A Review

4 citations , July 2021 in “Journal of Dermatological Treatment”

This meta-analysis reported that finasteride 1 mg/day significantly increased hair count in male androgenetic alopecia compared to placebo, but highlighted persistent sexual side effects and associated depression risk.

research Hair Growth Is Promoted by BeauTop via Expression of EGF and FGF-7

7 citations , April 2018 in “Molecular Medicine Reports”

This study found that BeauTop, a supplement containing several traditional Chinese herbs, may promote hair growth in mice with alopecia, potentially by modulating EGF and FGF-7 levels.

research Dutasteride in Androgenetic Alopecia: An Update

27 citations , March 2017 in “Current Clinical Pharmacology”

In this review, the authors discuss the pharmacology of dutasteride and compare its efficacy to finasteride for treating androgenetic alopecia, highlighting dutasteride's effectiveness demonstrated in several clinical trials.

research Drug Delivery to Hair Follicles

122 citations , March 2013 in “Expert opinion on drug delivery”

This review summarizes drug delivery strategies to hair follicles, highlighting physicochemical factors affecting penetration and the use of stimuli-responsive particulate carriers, but reports no new clinical findings.

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

152 citations , April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

This review describes minoxidil's hair regrowth mechanism and discusses dermatological applications, but reports no new clinical results, emphasizing the need for regular use and addressing allergic reactions.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations , February 2011 in “Journal of Dermatological Science”

This study found that topical minoxidil modestly extended the anagen phase in mice by activating β-catenin activity in dermal papilla cells.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , March 2004 in “Journal of Dermatological Science”

This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.