Co-Delivery of Bioactive Peptides by Nanoliposomes for Promotion of Hair Growth

The study developed and evaluated nanoliposomes (NLPs) for the transdermal co-delivery of copper peptide, acetyl tetrapeptide-3, and myristoyl pentapeptide-4 into hair follicles to promote hair growth. These bioactive peptides have been shown to stimulate cell proliferation, inflammation, angiogenesis, and protein synthesis, but their efficacy is limited by low skin absorption. The NLPs, which are biodegradable, biocompatible, and have low toxicity, were found to enhance the penetration of these peptides, specifically through the hair follicle pathway. The NLPs had a small and uniformly distributed particle size, high encapsulation efficiency, and high co-loading capacity for the peptides. The study concluded that NLPs could be an effective vehicle for delivering multiple hair-growth peptides and targeting hair follicle aggregation.