Skin-Permeable Liposome Improved Stability and Permeability of bFGF Against Skin of Mice With Deep Second-Degree Scald to Promote Hair Follicle Neogenesis Through Inhibition of Scar Formation

    September 2018 in “ Colloids and Surfaces B: Biointerfaces ”
    He-Lin Xu, Pian-Pian Chen, Lifen Wang, Meng-Qi Tong, Zi-hui Ou, Ying-Zheng Zhao, Jian Xiao, Ting-Ling Fu, Wei-Xue
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    TLDR A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.
    In the 2018 study, researchers developed a novel liposome (SP-bFGF-SF-LIP) containing basic fibroblast growth factor (bFGF) with a silk fibroin hydrogel core to enhance the stability and skin permeability of bFGF for treating deep second-degree scald wounds in mice. The liposome showed high encapsulation efficiency for bFGF, which remained significantly more stable in wound fluid containing MMP-9 compared to free bFGF. The treatment with SP-bFGF-SF-LIP led to improved hair follicle morphology, increased hair regrowth, and inhibited scar formation by reducing type I collagen density and increasing type III collagen density. The study concluded that SP-bFGF-SF-LIP could be a potential option for high-quality wound healing with effective scar inhibition and promotion of hair follicle neogenesis. The number of mice used in the study was not specified in the provided text.
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