Skin-Permeable Liposome Improved Stability and Permeability of bFGF Against Skin of Mice With Deep Second-Degree Scald to Promote Hair Follicle Neogenesis Through Inhibition of Scar Formation
September 2018
in “
Colloids and Surfaces B: Biointerfaces
”
TLDR A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.
In the 2018 study, researchers developed a novel liposome (SP-bFGF-SF-LIP) containing basic fibroblast growth factor (bFGF) with a silk fibroin hydrogel core to enhance the stability and skin permeability of bFGF for treating deep second-degree scald wounds in mice. The liposome showed high encapsulation efficiency for bFGF, which remained significantly more stable in wound fluid containing MMP-9 compared to free bFGF. The treatment with SP-bFGF-SF-LIP led to improved hair follicle morphology, increased hair regrowth, and inhibited scar formation by reducing type I collagen density and increasing type III collagen density. The study concluded that SP-bFGF-SF-LIP could be a potential option for high-quality wound healing with effective scar inhibition and promotion of hair follicle neogenesis. The number of mice used in the study was not specified in the provided text.
