The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro

July 2007 in “ Archives of Pharmacal Research ”

Hyun Keol Pyo, Hyeon Gyeong Yoo, Chong Hyun Won, Seung Ho Lee, Yong‐Kook Kang, Hee Chul Eun, Kwang Hyun Cho, Kyu Han Kim

tripeptide-copper complex AHK-Cu human hair follicles dermal papilla cells DPCs Bcl-2/Bax ratio apoptosis markers caspase-3 PARP copper peptide hair follicles

Studysummary A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells

56 citations , July 2005 in “Experimental Dermatology”

This study demonstrated that hair follicle-derived cells can induce hair follicle formation in an in vitro skin organ culture system using human retroauricular skin specimens.

research Limitations of Human Occipital Scalp Hair Follicle Organ Culture for Studying the Effects of Minoxidil as a Hair Growth Enhancer

30 citations , September 2004 in “Experimental Dermatology”

This study found that minoxidil did not significantly increase hair shaft elongation in ex vivo human hair follicle culture, questioning the suitability of this method for studying its hair-growth-promoting effects.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , March 2004 in “Journal of Dermatological Science”

This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro

29 citations , April 2003 in “Experimental dermatology”

In this study, in vitro growth of human hair follicles did not alter hair keratin expression patterns, maintaining follicle integrity and proper keratinization similar to in vivo conditions.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

21 citations , January 2002 in “Journal of Cutaneous Medicine and Surgery”

This study reports that finasteride treatment in men with androgenetic alopecia appears to restore caspase and XIAP expression in hair follicles to levels similar to those in individuals without the condition.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

research Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles

57 citations , November 1998 in “Wound Repair and Regeneration”

This research observed that dermal papilla cells have the potential to regenerate hair bulbs under preferred environmental conditions when associated with dermal sheath cells or exposed to specific growth factors.

research Whole Hair Follicle Culture

57 citations , October 1996 in “Dermatologic clinics”

This study found that using hyaluronic acid microneedles to deliver minoxidil significantly reduced hair loss in chemotherapy-induced alopecia mice, with only 10% of the dose used in topical applications.