The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro

    July 2007 in “ Archives of Pharmacal Research ”
    Hyun Keol Pyo, Hyeon Gyeong Yoo, Chong Hyun Won, Seung Ho Lee, Yong‐Kook Kang, Hee Chul Eun, Kwang Hyun Cho, Kyu Han Kim
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    TLDR A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.
    The study from 2007 found that a tripeptide-copper complex, AHK-Cu, stimulated the elongation of human hair follicles and the proliferation of dermal papilla cells (DPCs) at concentrations between 10^-12 and 10^-9 M. The research involved 240 hair follicles from three volunteers and showed that while AHK-Cu at 10^-9 M did not significantly reduce the number of apoptotic DPCs, it did increase the Bcl-2/Bax ratio and decreased levels of apoptosis markers caspase-3 and PARP. These findings suggest that AHK-Cu may promote hair growth by stimulating DPC proliferation and preventing apoptosis, indicating its potential as a therapeutic agent for hair growth promotion.
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