The Role of Lipids in Promoting Hair Growth Through HIF-1 Signaling Pathway

    November 2024 in “ Research Square (Research Square) ”
    Jieun Seo, Kinzo Matsumoto, Ayaka Nanmo, Shan Tung Tu, Do-Won Jeong, Yang‐Sook Chun, Lei Yan, Tatsuto Kageyama, Junji Fukuda
    Image of study
    TLDR Lipids may help treat hair loss by promoting hair growth through the HIF-1 pathway.
    This study investigates the role of lipids in hair growth, particularly through the HIF-1 signaling pathway. Researchers observed reduced lipid metabolism in the scalp tissues of patients with androgenetic alopecia. Supplementing lipids in culture mediums enhanced hair growth-related gene expression and the proliferation of human dermal papilla cells (DPCs). RNA-sequencing and HIF-1a knockdown experiments identified HIF-1a as a key regulator in lipid-induced upregulation of trichogenic genes. Additionally, lipids were shown to promote the elongation of hair-shaft-like structures in vitro. These findings suggest that targeting lipid metabolism and HIF-1 signaling could be a promising approach for treating hair loss.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 93 results

      community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

      in Research/Science  129 upvotes 1 month ago
      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  8 upvotes 2 years ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

      community Can anyone confidently say their erections are the same on fin ?

      in Chat  240 upvotes 10 months ago
      The conversation discusses the impact of finasteride on sexual function, with many users reporting reduced libido and weaker erections despite continuing the treatment to prevent hair loss. Some users suggest checking hormone levels or switching to different dosages or treatments like dutasteride, while others share mixed experiences regarding the severity of side effects.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  57 upvotes 3 weeks ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 7 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

    Related Research

    8 / 8 results