The Role of Lipids in Promoting Hair Growth Through HIF-1 Signaling Pathway

    November 2024 in “ Research Square (Research Square) ”
    Jieun Seo, Kinzo Matsumoto, Ayaka Nanmo, Shan Tung Tu, Do-Won Jeong, Yang‐Sook Chun, Lei Yan, Tatsuto Kageyama, Junji Fukuda
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    TLDR Lipids may help treat hair loss by promoting hair growth through the HIF-1 pathway.
    This study investigates the role of lipids in hair growth, particularly through the HIF-1 signaling pathway. Researchers observed reduced lipid metabolism in the scalp tissues of patients with androgenetic alopecia. Supplementing lipids in culture mediums enhanced hair growth-related gene expression and the proliferation of human dermal papilla cells (DPCs). RNA-sequencing and HIF-1a knockdown experiments identified HIF-1a as a key regulator in lipid-induced upregulation of trichogenic genes. Additionally, lipids were shown to promote the elongation of hair-shaft-like structures in vitro. These findings suggest that targeting lipid metabolism and HIF-1 signaling could be a promising approach for treating hair loss.
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