Synergistic Treatment of Androgenetic Alopecia with Follicular Co-Delivery of Minoxidil and Cedrol in Metal-Organic Frameworks Stabilized by Covalently Cross-Linked Cyclodextrins

    February 2024 in “ International Journal of Pharmaceutics ”
    Zhiyao He, Yongtai Zhang, Zhenda Liu, Teng Guo, Xinyi Ai, Yuanzhi He, Xinjuan Hou, Nianping Feng
    Image of study
    TLDR A new hair loss treatment combining minoxidil and cedrol improves hair growth and reduces side effects.
    The study developed a new hair follicle delivery system, MXD-CED@CDF, loaded with minoxidil and cedrol for effectively treating Androgenetic Alopecia (AGA). This system reduced the adverse reaction of minoxidil, improved drug release and follicular delivery performance, enhanced human dermal papilla cells' (hDPCs) viability and uptake of drugs, and developed biocompatibility with skin. It also presented premature initiation and prolongation of the anagen phase in the hair cycle, hair follicle differentiation, and hair regeneration. The study used human dermal papilla cells, male C57BL/6 mice, and New Zealand white rabbits for the experiments. The synergistic effect of minoxidil and cedrol showed excellent results in promoting hDPCs viability and treating AGA in C57BL/6 mice.
    Discuss this study in the Community →

    Research cited in this study

    36 / 36 results

    Related Community Posts Join

    6 / 1000+ results

      community Starting minoxidil and looking for a few tips

      in Minoxidil  7 upvotes 1 day ago
      The conversation is about using minoxidil for diffuse thinning after finasteride showed no regrowth. Tips include applying minoxidil directly to the scalp, considering potential shedding, and being cautious with combining tretinoin due to possible irritation.

      community Minoxidil (5% Rogaine foam) 0.5 Dutasteride

      in Minoxidil  15 upvotes 1 week ago
      A user shared their hair loss experience and treatment routine, which includes using Minoxidil (5% Rogaine foam) and Dutasteride 0.5, along with various supplements and natural oils. They reported positive results and emphasized the importance of liver health and thyroid function, despite skepticism from others about the effectiveness of supplements.

      community Scared of Twink death due to minoxidil

      in Minoxidil 1 week ago
      A 19-year-old is considering switching from topical to oral minoxidil to combat hair loss, despite concerns about increased body hair. They are currently using minoxidil, ketoconazole shampoo, and dutasteride, and are willing to accept the trade-off of more body hair for better scalp hair growth.

      community Foam minoxidil with Tretinoin (Which Tretinoin Strength?)

      in Minoxidil  2 upvotes 2 weeks ago
      The conversation discusses using foam minoxidil with tretinoin cream for hair loss, with users sharing experiences on tretinoin strengths of 0.025% and 0.05%. Some users report irritation with higher tretinoin concentrations and note that foam minoxidil may be less effective than liquid.

    Related Research

    1 / 1 results