Synthesis and Validation of Functional Nanogels as pH-Sensors in the Hair Follicle

    April 2017 in “ Macromolecular bioscience ”
    Mathias Dimde, Fitsum Feleke Sahle, Virginia Wycisk … Rainer Haag
    Studysummary In this study, researchers developed a pH-sensitive dendritic polyglycerol nanogel to measure pH inside hair follicles using an ex vivo porcine ear model, finding that the pH increases from 6.5 at the skin surface to 7.4 in deeper follicle areas, without observed toxicity.
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    Research cited in this study 5

    1. Dendritic Polyglycerol and N-Isopropylacrylamide Based Thermoresponsive Nanogels as Smart Carriers for Controlled Delivery of Drugs Through the Hair Follicle Nanoscale · 2016
    2. Hair Follicles as a Target Structure for Nanoparticles Journal of innovative optical health sciences/Journal of innovation in optical health science · 2015
    3. Penetration of Drugs Through Skin: A Complex Rate-Controlling Membrane 2012
    4. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    5. Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles Journal of Biomedical Optics · 2009