Dendritic Polyglycerol and N-Isopropylacrylamide Based Thermoresponsive Nanogels as Smart Carriers for Controlled Delivery of Drugs Through the Hair Follicle

    November 2016 in “ Nanoscale ”
    Fitsum Feleke Sahle, Michael Giulbudagian, Julián Bergueiro … Marcelo Calderón
    Studysummary In this study, researchers developed thermoresponsive nanogels that effectively penetrate hair follicles and release a model drug when triggered by temperature, demonstrating greater penetration for medium to large nanogels (300–500 nm) compared to smaller ones.
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    Research cited in this study 8

    1. Mechanistic Study of Decreased Skin Penetration Using a Combination of Sonophoresis with Sodium Fluorescein-Loaded PEGylated Liposomes with D-Limonene International journal of nanomedicine · 2015
    2. Hair Follicles as a Target Structure for Nanoparticles Journal of innovative optical health sciences/Journal of innovation in optical health science · 2015
    3. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    4. Measurement of Skin Permeation and Penetration of Nanoparticles for Their Safety Evaluation Biological and Pharmaceutical Bulletin · 2012
    5. Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions European journal of pharmaceutics and biopharmaceutics · 2009
    6. Follicular Targeting: A Promising Tool in Selective Dermatotherapy ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2005
    7. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    8. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004