Multi-Modal Imaging to Assess the Follicular Delivery of Zinc Pyrithione

    May 2022 in “ Pharmaceutics ”
    Sean E. Mangion, Lydia Sandiford, Yousuf Mohammed, Michael S. Roberts, Amy Holmes
    TLDR Zinc pyrithione dissolves quickly on the skin and in hair follicles, especially in smaller particles.
    This study used multi-modal imaging techniques, including multiphoton microscopy (MPM) and fluorescence lifetime imaging microscopy (FLIM), to assess the follicular delivery of Zinc Pyrithione (ZnPT) from various commercial antidandruff shampoos. The research found that ZnPT particles can penetrate up to 500 µm into hair follicles, with finer particles dissolving more rapidly and enhancing zinc detection. Massage application generally increased ZnPT penetration depth, although not significantly. The study highlighted the effectiveness of MPM-FLIM in optimizing ZnPT formulations for better therapeutic efficacy, despite limitations like time-consuming image acquisition and costly equipment. Future work should focus on optimizing particle size and formulation viscosity to improve delivery efficacy.
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