TLDR Zinc pyrithione dissolves quickly on the skin and in hair follicles, especially in smaller particles.
This study used multi-modal imaging techniques, including multiphoton microscopy (MPM) and fluorescence lifetime imaging microscopy (FLIM), to assess the follicular delivery of Zinc Pyrithione (ZnPT) from various commercial antidandruff shampoos. The research found that ZnPT particles can penetrate up to 500 µm into hair follicles, with finer particles dissolving more rapidly and enhancing zinc detection. Massage application generally increased ZnPT penetration depth, although not significantly. The study highlighted the effectiveness of MPM-FLIM in optimizing ZnPT formulations for better therapeutic efficacy, despite limitations like time-consuming image acquisition and costly equipment. Future work should focus on optimizing particle size and formulation viscosity to improve delivery efficacy.
Cited in this study
6 / 6 results
14 citations
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September 2021 in “International journal of molecular sciences” Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.
46 citations
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263 citations
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211 citations
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48 citations
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67 citations
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April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft” Shampoos are designed to clean and improve hair and scalp health, with specific ingredients for different hair types and conditions.