TLDR Zinc pyrithione dissolves quickly on the skin and in hair follicles, especially in smaller particles.
This study used multi-modal imaging techniques, including multiphoton microscopy (MPM) and fluorescence lifetime imaging microscopy (FLIM), to assess the follicular delivery of Zinc Pyrithione (ZnPT) from various commercial antidandruff shampoos. The research found that ZnPT particles can penetrate up to 500 µm into hair follicles, with finer particles dissolving more rapidly and enhancing zinc detection. Massage application generally increased ZnPT penetration depth, although not significantly. The study highlighted the effectiveness of MPM-FLIM in optimizing ZnPT formulations for better therapeutic efficacy, despite limitations like time-consuming image acquisition and costly equipment. Future work should focus on optimizing particle size and formulation viscosity to improve delivery efficacy.
14 citations,
September 2021 in “International journal of molecular sciences” Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.
62 citations,
November 2016 in “Nanoscale” Medium to larger nanogels effectively deliver drugs through hair follicles when heated.
46 citations,
September 2011 in “British journal of dermatology/British journal of dermatology, Supplement” Effective dandruff treatment requires delivering antifungal agents to the scalp follicular infundibulum.
263 citations,
February 2011 in “Journal of Controlled Release” Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.
211 citations,
February 2009 in “European journal of pharmaceutics and biopharmaceutics” Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.
48 citations,
May 2008 in “Drug Discovery Today: Disease Mechanisms” Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.
67 citations,
April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft” Shampoos are designed to clean and improve hair and scalp health, with specific ingredients for different hair types and conditions.
151 citations,
May 2014 in “American Journal of Clinical Dermatology” Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.
66 citations,
June 2018 in “International Journal of Women's Dermatology” No cure for female pattern hair loss, but various effective treatments exist.
43 citations,
October 2002 in “International Journal of Cosmetic Science” All three shampoos reduced dandruff and hair loss, but ketoconazole and piroctone olamine also made hair thicker.
14 citations,
September 2021 in “International journal of molecular sciences” Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.
12 citations,
May 2017 in “Journal of pharmaceutical and biomedical analysis” The method shows that zinc pyrithione and climbazole from anti-dandruff shampoo effectively reach the scalp.
