Multi-Modal Imaging to Assess the Follicular Delivery of Zinc Pyrithione

    May 2022 in “ Pharmaceutics ”
    Sean E. Mangion, Lydia Sandiford, Yousuf Mohammed, Michael S. Roberts, Amy Holmes
    TLDR Zinc pyrithione dissolves quickly on the skin and in hair follicles, especially in smaller particles.
    This study used multi-modal imaging techniques, including multiphoton microscopy (MPM) and fluorescence lifetime imaging microscopy (FLIM), to assess the follicular delivery of Zinc Pyrithione (ZnPT) from various commercial antidandruff shampoos. The research found that ZnPT particles can penetrate up to 500 µm into hair follicles, with finer particles dissolving more rapidly and enhancing zinc detection. Massage application generally increased ZnPT penetration depth, although not significantly. The study highlighted the effectiveness of MPM-FLIM in optimizing ZnPT formulations for better therapeutic efficacy, despite limitations like time-consuming image acquisition and costly equipment. Future work should focus on optimizing particle size and formulation viscosity to improve delivery efficacy.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 907 results

      community Shoutout to Zinc pyrithione and Piroctone olamine

      in Product  3 upvotes 7 months ago
      Zinc pyrithione and piroctone olamine are effective for reducing hair shedding, possibly more so than ketoconazole. There is a concern about zinc pyrithione shampoo interfering with minoxidil, but it's unclear if this is proven.

      community Hot weather causing hair shedding?

      in Minoxidil  3 upvotes 2 weeks ago
      Hot weather can increase hair shedding, possibly due to dehydration and active sebaceous glands. Using shampoos with salicylic acid or zinc pyrithione may help; daily anti-inflammatory use is not recommended.

      community 23M. 2 month progress 0.5 mg DUT and 5% min twice daily

      in Finasteride/Dutasteride  1 upvotes 3 months ago
      A 23-year-old male is using 0.5 mg dutasteride daily, 5% minoxidil twice daily, and ketoconazole with zinc pyrithione shampoo twice a week to address diffused thinning and hair loss. He is seeking advice on whether his hair will regrow and if additional treatments are needed.

      community Shampoo Options? Other than Ketoconazole

      in Hair Systems  3 upvotes 4 months ago
      Tea Tree Special shampoo and Purador are discussed as alternatives to Ketoconazole shampoo for hair loss. Other anti-dandruff shampoos mentioned include those with Zinc Pyrithione, Salicylic Acid, and Selenium Sulfide.

    Similar Research

    5 / 1000+ results