Mechanistic Study of Decreased Skin Penetration Using a Combination of Sonophoresis with Sodium Fluorescein-Loaded PEGylated Liposomes with D-Limonene

    December 2015 in “ International journal of nanomedicine ”
    Worranan Rangsimawong, Praneet Opanasopit, Theerasak Rojanarata, Tanasait Ngawhirunpat
    Studysummary This study found that low-frequency sonophoresis significantly decreased the skin penetration of sodium fluorescein-loaded PEGylated liposomes with D-limonene and affected percutaneous absorption by partially plugging hair follicle orifices.
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    Research cited in this study 3

    1. Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction European Journal of Pharmaceutics and Biopharmaceutics · 2012
    2. Use of the Skin Sandwich Technique to Probe the Role of Hair Follicles in Sonophoresis International journal of pharmaceutics · 2011
    3. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005