Novel Synergistic Approach for Bioactive Macromolecules: Evaluating the Efficacy of Goat Placenta Extract in PEGylated Liposomes and Microspicules for Chemotherapy-Induced Hair Loss

    August 2024 in “ Pharmaceuticals ”
    Phitjira Sanguanboonyaphong, Phaijit Sritananuwat, Sureewan Duangjit, Anyamanee Lapmag, Watcharin Pumchan, Tanasait Ngawhirunpat, Praneet Opanasopit, Worranan Rangsimawong
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    TLDR Goat placenta extract in a special delivery system improved hair growth and thickness in chemotherapy patients.
    The study explores the use of goat placenta (GP) extract in PEGylated liposomes and microspicules (PL-MS) to treat chemotherapy-induced hair loss. Conducted with 11 female participants over 12 weeks, the GP extract-loaded PL-MS formulation significantly improved hair growth, density, and thickness without causing skin irritation. The GP extract, rich in growth factors, enhanced dermal papilla cell proliferation and protected against chemotherapy-induced damage. The PL-MS system effectively delivered bioactive macromolecules through the skin, increasing permeability by 14.72-fold. Despite promising results, the small sample size suggests that larger studies are needed to confirm these findings.
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