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GlossaryConfocal Microscopy

uses laser light to create detailed, three-dimensional images

Confocal Microscopy, also known as Confocal Laser Scanning Microscopy (CLSM), is an advanced imaging technique that uses laser light to scan samples and create high-resolution, three-dimensional images. By focusing on a specific plane within the sample and excluding out-of-focus light, it provides clearer and more detailed images than traditional microscopy, making it particularly useful for studying complex structures like hair follicles and skin tissues in both research and medical diagnostics.

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Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

research Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

21 citations, December 2016 in “European journal of pharmaceutics and biopharmaceutics”

Nano-sized lipid particles increase dexamethasone's skin penetration and create a reservoir in the skin layers.

research Confocal Laser Scanning Microscopy as a Tool for the Investigation of Skin Drug Delivery Systems and Diagnosis of Skin Disorders

4 citations, March 2013 in “InTech eBooks”

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

research Development and Skin Penetration Pathway Evaluation Using Confocal Laser Scanning Microscopy of Microemulsions for Dermal Delivery Enhancement of Finasteride

1 citations, December 2022 in “Pharmaceutics”

Finasteride-loaded microemulsions can effectively enhance skin delivery for treating hair loss.

research Follicular Transport Route: Research Progress and Future Perspectives

211 citations, February 2009 in “European journal of pharmaceutics and biopharmaceutics”

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

research Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis

159 citations, July 2014 in “Molecular pharmaceutics”

New micelle nanocarriers deliver Tacrolimus more effectively to skin layers for psoriasis treatment than the current Protopic ointment.

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community Verteporfin and Microneedling

in Treatments 6 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.