Penetration of Drugs Through Skin: A Complex Rate-Controlling Membrane

    June 2012
    Marie‐Alexandrine Bolzinger, Stéphanie Briançon, Jocelyne Pelletier, Yves Chevalier
    Studysummary This review discusses recent advances in skin penetration mechanisms, specifically focusing on the enhanced understanding of the follicular pathway and its implications for transdermal therapies, immune system targeting, and nanoparticle safety.
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    Research cited in this study 11

    1. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    2. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    3. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    4. Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions European journal of pharmaceutics and biopharmaceutics · 2009
    5. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
    6. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    7. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    8. Stem Cells and Their Niches Science · 2006
    9. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    10. Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    11. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004