Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles

    September 2020 in “ Sensors ”
    Dennis Kaden, Lars Dähne, Fanny Knorr, Heike Richter, Jürgen Lademann, Martina C. Meinke, Alexa Patzelt, Maxim E. Darvin, Sora Jung
    The study investigated the pH gradient within human hair follicles using melamine formaldehyde particles containing fluorescent pH indicators, applied to 40 scalp hairs from 8 individuals. Confocal laser scanning microscopy revealed a significant pH gradient from the hair sheath to the external hair shaft, with pH values decreasing from 6.63 ± 0.09 at the hair sheath to 6.17 ± 0.09 at the external hair shaft. This suggested a pH increase towards the hair root, providing insights into the in vivo pH environment of hair follicles, which could be useful for targeted drug delivery applications.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 90 results

      community the post about vitamin c and pH levels is legit.

      in Update  12 upvotes 3 years ago
      Using vitamin C in shampoo to adjust pH levels can improve hair health and reduce oiliness and dandruff. The user mixed vitamin C powder with conditioner, achieving positive results.

      community Vitamin C and hair growth PH levels

      in Product  31 upvotes 3 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community How to stop flaky skin from Minoxidil (no foam)?

      in Minoxidil  2 upvotes 8 months ago
      Minoxidil can cause flaky skin, and users suggest using ketoconazole 2% shampoo three times a week and a pH-balanced shampoo on other days to help manage it. Argan oil was considered but may leave hair oily.

      community 1 year 1 month into fin, new regrowth

      in Chat  8 upvotes 1 year ago
      The user increased finasteride to 1mg daily, stopped using ketoconazole and pyrithione zinc shampoos, and started using regular pH balanced shampoo with tea tree oil, rosemary/peppermint oil, and microneedling. They are now seeing new hair regrowth at the hairline and temples.

      community I’m Quitting ketoconazole shampoo

      in Ketoconazole  2 upvotes 1 year ago
      A user is quitting ketoconazole shampoo, believing it worsened their hair condition, and plans to use clarifying, keratin, and pH balanced moisturizing shampoos instead. Another user suggests using conditioner after ketoconazole to prevent dryness.

    Similar Research

    5 / 1000+ results