Significance of the Follicular Pathway for Dermal Substance Penetration Quantified by Laser Doppler Flowmetry

    August 2015 in “ Journal of biophotonics ”
    Staffan Vandersee, U. Erdmenger, Alexa Patzelt … Jürgen Lademann
    Studysummary This study found that applying benzyl nicotinate on open hair follicles led to a significant increase in blood flow, highlighting the role of the follicular pathway in epidermal penetration.
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    Research cited in this study 7

    1. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    2. Drug Delivery with Topically Applied Nanoparticles: Science Fiction or Reality? Skin pharmacology and physiology · 2013
    3. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    4. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    5. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004
    6. Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin European journal of pharmaceutical sciences · 2003
    7. Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes Journal of Pharmaceutical Sciences · 1997