Development of Minoxidil-Loaded Double Emulsion PLGA Nanoparticles for the Treatment of Hair Loss
May 2022
in “
Journal of Industrial and Engineering Chemistry
”
New to Minoxidil? There is a guide in the encyclopedia. Read the guide → Studysummary This study observed that minoxidil-loaded nanoparticles significantly enhanced skin penetration and hair regrowth in mice within three weeks, without ethanol and propylene glycol, suggesting they are a promising delivery method for treating hair loss. Our plain-language summary of this paper — not a Tressless recommendation.
Researchers developed minoxidil-loaded double emulsion nanoparticles (MXD-DE-NPs) using PLGA and surfactants to enhance the delivery of minoxidil (MXD) for hair loss treatment. The nanoparticles, with a size of 137.8 ± 0.814 nm and an encapsulation efficiency of 43%, showed no aggregation in aqueous conditions at 1% w/v MXD concentration without ethanol and propylene glycol. In human follicular dermal papilla cells, the nanoparticles demonstrated fast cellular uptake and no significant toxicity. When applied to the skin of shaved mice, the nanoparticles penetrated efficiently and promoted hair regrowth over three weeks, comparable to traditional MXD formulas. These findings suggest that MXD-DE-NPs are a promising carrier for MXD in treating hair loss.
