Development of Minoxidil-Loaded Double Emulsion PLGA Nanoparticles for the Treatment of Hair Loss

May 2022 in “ Journal of Industrial and Engineering Chemistry ”

Seongryeong Han, Hyung Suk Jang, Joon Hyung Shim, Minjeong Kang, Ye-Eun Lee, Ji-Won Park, Min-Hee Kim, Gulimila Abudureyimu, Dong-Youn Lee, Heebeom Koo

minoxidil double emulsion nanoparticles PLGA surfactants human follicular dermal papilla cells cellular uptake hair regrowth traditional MXD formulas Rogaine

TLDR Minoxidil-loaded nanoparticles effectively promote hair regrowth and are safe for use.

Researchers developed minoxidil-loaded double emulsion nanoparticles (MXD-DE-NPs) using PLGA and surfactants to enhance the delivery of minoxidil (MXD) for hair loss treatment. The nanoparticles, with a size of 137.8 ± 0.814 nm and an encapsulation efficiency of 43%, showed no aggregation in aqueous conditions at 1% w/v MXD concentration without ethanol and propylene glycol. In human follicular dermal papilla cells, the nanoparticles demonstrated fast cellular uptake and no significant toxicity. When applied to the skin of shaved mice, the nanoparticles penetrated efficiently and promoted hair regrowth over three weeks, comparable to traditional MXD formulas. These findings suggest that MXD-DE-NPs are a promising carrier for MXD in treating hair loss.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia

9 citations, February 2022 in “European Journal of Pharmaceutics and Biopharmaceutics”

A new treatment for hair loss uses tiny lipid carriers to deliver a mix of minoxidil and latanoprost directly to hair follicles, promoting hair growth and being well tolerated by the skin.

research A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia

14 citations, October 2020 in “Natural Products and Bioprospecting”

Various treatments, including FDA-approved drugs, natural products, and oral supplements, can help with hair loss, but a patient's medical history and potential allergies should be considered when choosing a treatment.

research Transdermal Delivery of Minoxidil Using HA-PLGA Nanoparticles for the Treatment of Alopecia

24 citations, October 2019 in “Biomaterials Research”

Minoxidil in HA-PLGA nanoparticles effectively treats alopecia through skin delivery.

research Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice

28 citations, September 2019 in “International Journal of Nanomedicine”

Minoxidil nanoparticles can potentially be a more effective treatment for hair growth than current treatments.

research Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial

53 citations, August 2019 in “Journal of The American Academy of Dermatology”

Oral minoxidil and topical minoxidil 5% both effectively improve female-pattern hair loss with safe side effects.

research Skin Wound Healing in Humans and Mice: Challenges in Translational Research

276 citations, December 2017 in “Journal of Dermatological Science”

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Related Research

6 / 6 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations, August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review

1 citations, February 2019 in “PubMed”

Minoxidil is effective in treating various types of hair loss and can improve quality of life, with combination therapies showing increased effectiveness.

research Disorders of Hair

July 2013 in “DeckerMed Medicine”

The document's conclusion cannot be provided because the document is not readable or understandable.

research Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica

24 citations, February 1987 in “Drugs”

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

research Alopecia Areata Treated With Topical Minoxidil

78 citations, April 1984 in “Archives of Dermatology”

Minoxidil can help regrow hair in alopecia areata patients.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations, October 1983 in “BMJ”

Minoxidil helps hair regrowth in alopecia patients, with 16 having good results and no side effects.

Development of Minoxidil-Loaded Double Emulsion PLGA Nanoparticles for the Treatment of Hair Loss

Research cited in this study

research Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia

research A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia

research Transdermal Delivery of Minoxidil Using HA-PLGA Nanoparticles for the Treatment of Alopecia

research Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice

research Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial

research Skin Wound Healing in Humans and Mice: Challenges in Translational Research

Related Community Posts Join

community The theory that explains everything. Please help me make this big!

community latanoprost, minoxidil and biotin 3/20/23 vs 5/21/23 same spot

community Frequency/strength of topical minoxidil application

community Any info on where to buy solution for diluting my topical solution from 1mg/ml to 1mg/2ml

community 3 months progress Fin 0.5mg/day, 1x minox 5%, keto shampoo every 3 days and microneedling 1.5mm a week

community An Interesting Study With a Decent Sample Size Finding Caffeine Liquid to Have Similar Effectiveness to Minoxidil