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Glossaryp38 MAPK

enzyme involved in cellular stress and inflammation responses

p38 MAPK, or p38 mitogen-activated protein kinase, is an enzyme that plays a crucial role in cellular responses to stress and inflammation. It is part of a signaling pathway that helps cells react to various external stimuli, such as UV radiation, heat shock, and cytokines, by regulating the expression of specific genes involved in inflammation, cell differentiation, and apoptosis (programmed cell death). This pathway is significant in various biological processes and diseases, including cancer, cardiovascular diseases, and inflammatory conditions.

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Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

10 citations, December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research Factors Regulating Quiescent Stem Cells: Insights from the Intestine and Other Self-Renewing Tissues

8 citations, December 2015 in “The Journal of Physiology”

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

research Elucidating the Anti-Aging Mechanism of Si Jun Zi Tang by Integrating Network Pharmacology and Experimental Validation In Vivo

6 citations, May 2022 in “Aging”

Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

research Malva Verticillata Seed Extracts Upregulate the Wnt Pathway in Human Dermal Papilla Cells

25 citations, August 2015 in “International Journal of Cosmetic Science”

Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.

research Protective Effect of Iris Germanica L. Rhizome-Derived Exosome Against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes

October 2023 in “Applied sciences”

Iris germanica rhizome-derived exosomes help protect skin cells from oxidative stress and aging.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Aronia Chokeberry and Cyanidin 3-O-arabinoside for Hair Growth (AGA) Study

in Research/Science 14 upvotes 10 months ago

A natural compound called C3A from Aronia Chokeberry can help prevent hair loss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.