Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

    December 2017 in “ Chemosphere ”
    Yang Yang, Zhaoqing Fang, Yuhua Dai … Xiaoling Xu
    Studysummary In this study, BPA rapidly increased dendritic spine and synapse densities in cultured rat hippocampal neurons, with involvement of estrogen receptors and ERK1/2 and p38 pathways, but disrupted dihydrotestosterone's effects on synaptic plasticity.
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    Research cited in this study 1

    1. Neo-Synthesis of Estrogenic or Androgenic Neurosteroids Determine Whether Long-Term Potentiation or Depression Is Induced in Hippocampus of Male Rat Frontiers in Cellular Neuroscience · 2015