Systemic Minoxidil Accidental Exposure in a Pediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

September 2021 in “ Journal of Clinical Medicine ”

Manuel Sánchez‐Díaz, David López‐Delgado, Trinidad Montero‐Vílchez, Luis Salvador‐Rodríguez, Alejandro Molina‐Leyva, Jesús Tercedor‐Sánchez, Salvador Arias‐Santiago

minoxidil hypertrichosis oral minoxidil Rogaine

Studysummary This study observed that in children who unintentionally consumed high-dose oral minoxidil, 65% developed hypertrichosis, predominantly on the face, and 15% experienced mild systemic side effects. Our plain-language summary of this paper — not a Tressless recommendation.

This study examined the effects of accidental high-dose oral minoxidil exposure in 20 pediatric patients, aged 2 months to 13 years, due to contaminated omeprazole. The primary side effect was hypertrichosis, observed in 65% of patients, primarily on the face, with a mean latency of 24.31 days. Systemic side effects were mild, affecting 15% of patients, with symptoms like diarrhea, anxiety, headache, and facial edema. The study suggested that hypertrichosis was linked to treatment duration rather than dosage, indicating individual variations in response. These findings provided insights into minoxidil's effects in children, potentially informing future pediatric alopecia treatments.

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