Systemic Minoxidil Accidental Exposure in a Pediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

    September 2021 in “ Journal of Clinical Medicine ”
    Manuel Sánchez‐Díaz, David López‐Delgado, Trinidad Montero‐Vílchez … Salvador Arias‐Santiago
    Studysummary This study observed that in children who unintentionally consumed high-dose oral minoxidil, 65% developed hypertrichosis, predominantly on the face, and 15% experienced mild systemic side effects.
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    Research cited in this study 19

    1. Low-Dose Oral Minoxidil Improves Global Hair Density and Length in Children with Loose Anagen Hair Syndrome British Journal of Dermatology · 2020
    2. Characterization and Management of Hypertrichosis Induced by Low-Dose Oral Minoxidil in the Treatment of Hair Loss Journal of The American Academy of Dermatology · 2020
    3. Topical and Oral Minoxidil for Hair Disorders in Pediatric Patients: What Do We Know So Far? Dermatologic Therapy · 2020
    4. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    5. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    6. Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability and the Five C’s of Oral Therapy Dermatologic Therapy · 2018
    7. Low-Dose Daily Aspirin Reduces Topical Minoxidil Efficacy in Androgenetic Alopecia Patients Dermatologic Therapy · 2018
    8. Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase International Journal of Molecular Sciences · 2017
    9. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    10. Cardiovascular Effects of Ingesting Topical Minoxidil in Pediatric Patients Pediatric emergency care · 2014
    11. Topical Use of Minoxidil in Children and Systemic Side Effects Dermatology · 2007
    12. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    13. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    14. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    15. Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia Clinics in Dermatology · 1988
    16. Minoxidil for Control of Acute Blood Pressure Elevation in Chronically Hypertensive Children Pediatrics · 1986
    17. Severe Hypertension in Children With Renal Disease: Treatment With Minoxidil American Journal of Kidney Diseases · 1983
    18. Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use Drugs · 1981
    19. Minoxidil Therapy in Children with Severe Hypertension The Journal of Pediatrics · 1977

    Related research 7

    1. Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata Indian Dermatology Online Journal · 2017
    2. Minoxidil Induced Hypertrichosis in a 2-Year-Old Child F1000Research · 2013
    3. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    4. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    5. Generalized Hypertrichosis After Treatment With Topical Minoxidil Clinical and Experimental Dermatology · 1994
    6. Hypertrichosis Due to Minoxidil British Journal of Dermatology · 1979
    7. Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory PubMed · 1977