Minoxidil Therapy in Children with Severe Hypertension

May 1977 in “ The Journal of Pediatrics ”

Paul S. Lietman, Alfred J. Pennisi, Masato Takahashi, Bram H. Bernstein, Bernhard H. Singsen, Christel H. Uittenbogaart, Robert B. Ettenger, Mohammad H. Malekzadeh, Virgil Hanson, Richard N. Fine

minoxidil hirsutism Rogaine

TLDR Minoxidil helps lower high blood pressure in kids, but can cause fluid retention and hair growth.

The study investigated the use of minoxidil therapy in six children with severe hypertension. The results showed that minoxidil is an effective antihypertensive agent, but the major side effect was fluid retention. Hirsutism was also observed in some patients. The authors recommended that minoxidil therapy should be limited to children with severe hypertension resistant to conventional, oral antihypertensive medications.

View this study on jpeds.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Long-Term Treatment of Severe Hypertension with Minoxidil, Propranolol, and Furosemide

55 citations, October 1975 in “Circulation”

Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.

$Minoxidil in Refractory Hypertension$

research Minoxidil in Refractory Hypertension

17 citations, April 1975 in “The Journal of Pediatrics”

Minoxidil effectively controls severe high blood pressure in children with few side effects.

Control Plasma Renin Activity and Changes in Sympathetic Tone as Determinants of Minoxidil-Induced Increase in Plasma Renin Activity

research Control Plasma Renin Activity and Changes in Sympathetic Tone as Determinants of Minoxidil-Induced Increase in Plasma Renin Activity

57 citations, February 1975 in “Journal of Clinical Investigation”

Minoxidil boosts plasma renin activity, influenced by control plasma renin activity and changes in sympathetic tone.

research Differential Effects of Propranolol on Heart Rate and Plasma Renin Activity in Patients Treated with Minoxidil

25 citations, December 1974 in “Clinical Pharmacology & Therapeutics”

Propranolol affects heart rate and renin levels in minoxidil-treated patients.

$Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension$

research Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension

180 citations, July 1973 in “The New England Journal of Medicine”

Minoxidil effectively lowers blood pressure with few side effects.

research Minoxidil in Severe Hypertension with Renal Failure

100 citations, March 1973 in “American Journal of Cardiology”

Minoxidil effectively lowers blood pressure without major side effects.

Similar Research

6 / 1000+ results

research Trichoscan: Results Using a 5% Minoxidil Topical Solution in Men with Androgenetic Alopecia

March 2004 in “Journal of The American Academy of Dermatology”

Minoxidil solution increases hair growth; Shampoo B best for dandruff; infliximab helps pemphigus vulgaris.

research Caffeine and Its Role in Regulating Androgenetic Alopecia

February 2021

Caffeine can potentially treat common hair loss by counteracting hair follicle shrinkage caused by hormones.

research Polycystic Ovary Syndrome (PCOS) Trilogy: A Translational and Clinical Review

26 citations, August 2008 in “Clinical endocrinology”

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

research Direct-Acting Vasodilators

40 citations, July 2011 in “The journal of clinical hypertension”

Hydralazine and minoxidil are blood pressure medications that relax blood vessels, with potential side effects like rapid heartbeat and fluid retention, and are used for severe or pregnancy-related hypertension.

$Treatment of Refractory Hypertension$

research Treatment of Refractory Hypertension

51 citations, April 1982 in “Lancet”

Most patients with hard-to-treat high blood pressure can be managed effectively with various treatments, but no single treatment is perfect.

research Drug-Induced Hair Disorders

40 citations, August 2006 in “Current Drug Safety”

Some drugs can cause hair loss, excessive growth, or color changes, often reversible but sometimes permanent.

Minoxidil Therapy in Children with Severe Hypertension

Research cited in this study

research Long-Term Treatment of Severe Hypertension with Minoxidil, Propranolol, and Furosemide

research Minoxidil in Refractory Hypertension

research Control Plasma Renin Activity and Changes in Sympathetic Tone as Determinants of Minoxidil-Induced Increase in Plasma Renin Activity

research Differential Effects of Propranolol on Heart Rate and Plasma Renin Activity in Patients Treated with Minoxidil

research Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension

research Minoxidil in Severe Hypertension with Renal Failure

Related Community Posts Join

community Minoxidil seems logistically impossible and impractical to use

community 2,5 months progress on topical minoxidil

community I am having Success with RU58841 and 1mm Derma Roller

community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

community AA and Hirsutism but T levels are normal

community (comment) providing facts on people talking nonsense about minoxidil and BP-medicaton in general