Minoxidil in Refractory Hypertension

April 1975 in “ The Journal of Pediatrics ”

Sudesh P Makker

TLDR Minoxidil effectively controls severe high blood pressure in children with few side effects.

This paper from 1975 describes the successful use of minoxidil, a new vasodilator, to treat a 10-year-old girl with life-threatening hypertension following a renal transplant. The girl's blood pressure remained controlled and the renal transplant functioned well during 9 months of minoxidil therapy, with no serious side effects except for moderate hypertrichosis. The paper suggests that minoxidil can be used to control refractory, life-threatening hypertension in children. The report also discusses the pharmacologic properties of minoxidil and its effectiveness in reducing blood pressure in animals and humans.

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Research cited in this study

4 / 4 results

$Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension$

research Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension

180 citations, July 1973 in “The New England Journal of Medicine”

Minoxidil effectively lowers blood pressure with few side effects.

research Minoxidil in Severe Hypertension with Renal Failure

100 citations, March 1973 in “American Journal of Cardiology”

Minoxidil effectively lowers blood pressure without major side effects.

research Pharmacologic Properties of Minoxidil: A New Hypotensive Agent

55 citations, March 1973 in “PubMed”

Minoxidil is a new drug that lowers blood pressure.

research Pharmacokinetic Studies of Minoxidil

90 citations, May 1972 in “Clinical Pharmacology & Therapeutics”

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

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$Minoxidil in Refractory Hypertension$

research Minoxidil in Refractory Hypertension

17 citations, April 1975 in “The Journal of Pediatrics”

Minoxidil effectively controls severe high blood pressure in children with few side effects.