In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus Racemosus Root as Anti-Sebum and Pore-Minimizing Active Ingredients

    February 2022 in “ Molecules ”
    Warintorn Ruksiriwanich, Chiranan Khantham, Pichchapa Linsaenkart … Korawan Sringarm
    Studysummary This study found that Asparagus racemosus root extract significantly reduced facial sebum production and pore size in male volunteers, suggesting potential application as an anti-sebum ingredient in cosmetics.
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    Research cited in this study 8

    1. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021
    2. An Updated Review of the Sebaceous Gland and Its Role in Health and Diseases Part 1: Embryology, Evolution, Structure, and Function of Sebaceous Glands Dermatologic Therapy · 2020
    3. Is There a Role for 5α-Reductase Inhibitors in Transgender Individuals? International Journal of Andrology · 2020
    4. A Comprehensive Review of Acne Vulgaris Clinical research in dermatology · 2019
    5. Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex Evidence-based Complementary and Alternative Medicine · 2015
    6. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    7. Potency of a Novel Saw Palmetto Ethanol Extract, SPET-085, for Inhibition of 5α-Reductase II Advances in Therapy · 2010
    8. Androgen Action on Human Skin – From Basic Research to Clinical Significance Experimental dermatology · 2004