A Network Pharmacology-Based Approach to Explore Mechanism of Action of Medicinal Herbs for Alopecia Treatment

    February 2022 in “ Scientific Reports ”
    Jungtae Leem, Won-Mo Jung, Hi-Joon Park, Kyuseok Kim
    Studysummary This study suggests that 20 vital medicinal herbs may exert therapeutic effects on alopecia by regulating specific target genes and proteins, offering insights into their novel mechanisms distinct from conventional drugs.
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    Research cited in this study 15

    1. A Comprehensive Review of Biochemical Factors in Herbs and Their Constituent Compounds in Experimental Studies on Alopecia Journal of Ethnopharmacology · 2020
    2. Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review International Journal of Molecular Sciences · 2020
    3. Herbal Preparations for the Treatment of Hair Loss Archives of Dermatological Research · 2019
    4. Meta-Analysis on the Efficacy and Safety of Traditional Chinese Medicine as Adjuvant Therapy for Refractory Androgenetic Alopecia Evidence-based Complementary and Alternative Medicine · 2019
    5. TREM2+ Macrophages Inhibit Hair Growth by Producing Oncostatin M Cell Stem Cell · 2019
    6. Phospholipase A2 in Skin Biology: New Insights from Gene-Manipulated Mice and Lipidomics Inflammation and Regeneration · 2018
    7. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review Skin appendage disorders · 2018
    8. Exploring the Combination and Modular Characteristics of Herbs for Alopecia Treatment in Traditional Chinese Medicine: An Association Rule Mining and Network Analysis Study BMC Complementary and Alternative Medicine · 2018
    9. Hair Loss: Common Causes and Treatment PubMed · 2017
    10. Acquired Localized Hypertrichosis Induced by Rivastigmine Case reports in dermatological medicine · 2016
    11. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    12. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    13. Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles International Journal of Molecular Medicine · 2011
    14. Alopecia Areata: A New Treatment Plan Clinical, cosmetic and investigational dermatology · 2011
    15. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993