Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking

The study explores the mechanisms and molecular targets of Taohong Siwu Decoction (THSWD) for treating androgenetic alopecia (AGA) using network pharmacology and molecular docking. It identifies 69 active compounds and 202 drug-related targets from THSWD, mapping them to 1158 AGA-related genes, resulting in 45 common target genes. Key compounds like luteolin, quercetin, and kaempferol interact with targets involved in oxidative stress and cell proliferation. The study highlights six core genes (AKT1, TP53, JUN, CASP3, CTNNB1, MYC) and confirms strong binding interactions, suggesting that THSWD may promote hair growth by regulating oxidative stress and apoptosis pathways, supporting its potential as a multi-target treatment for AGA.