Identifying the Active Components and Mechanisms of Persicae Semen in Treating Androgenetic Alopecia: Insights from Network Pharmacology and Experimental Evaluations

    April 2025 in “ Journal of Ethnopharmacology
    Xiaojuan Li, Xiaoli Liu, Bin Li, Ziyi Liu, Shiqi Guo, Sha Xiong, Ting Xiao, Siwen Jiao, Yu Chen, Yuehong Xu
    TLDR Amygdalin in Persicae Semen may help treat hair loss by promoting hair growth and regulating key pathways.
    The study investigates the active components and mechanisms of Persicae Semen (TR) in treating androgenetic alopecia (AGA) using advanced techniques like UPLC-Q-TOF-MS, network pharmacology, and molecular docking. Amygdalin (Am), identified as the main active compound in TR, was found to promote hair growth by influencing the Wnt/β-catenin and VEGF pathways. Additionally, Am can regulate androgen receptor (AR) and 5α-reductase, which are crucial in AGA development. These findings provide a foundation for the clinical use of TR in AGA treatment, offering a potential alternative to current treatments with significant side effects.
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