Active Pharmaceutical Ingredient-Ionic Liquids Assisted Follicular Co-Delivery of Ferulic Acid and Finasteride for Enhancing Targeted Anti-Alopecia

December 2023 in “ International Journal of Pharmaceutics ”

Tiaojun Xiao, Bin Li, Rongrong Lai, Ziyi Liu, Shiyun Xiong, Xiaojuan Li, Zhen Yao, Jing Song, Yawei Tang, Yi Lü, Yang Xu

ferulic acid finasteride dihydrotestosterone androgenetic alopecia human dermal papilla cells active pharmaceutical ingredient ionic liquid hair follicle pathway FA FIN DHT hDPCs API IL

TLDR The new delivery system improves treatment for hair loss by enhancing drug absorption and effectiveness.

The study synthesized an active pharmaceutical ingredient ionic liquid (API IL) based on choline and ferulic acid (FA), and constructed a finasteride (FIN)-loaded system. This system increased the solubility of FA and FIN and enhanced their permeation and retention, primarily through the hair follicle pathway. The FIN-loaded system was found to regulate mRNA expression in dihydrotestosterone (DHT)-irritated human dermal papilla cells (hDPCs), and demonstrated synergistic therapeutic efficacy for androgenetic alopecia. This suggests that the API IL-assisted follicular co-delivery of FA and FIN provides a new approach for targeted anti-alopecia treatment.

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