Regulatory Pathways Implicated in Male Androgenetic Alopecia Pathogenesis

November 2017 in “ British Journal of Dermatology ”

Elaine G.Y. Chew

androgenetic alopecia AGA androgen Wnt/B-cat TGFB BMP hair follicle formation hair follicle differentiation immune response autoimmune hair follicle inflammation male pattern baldness Wnt signaling pathway TGF-beta bone morphogenetic proteins hair follicle development hair follicle growth immune system response autoimmune inflammation

TLDR Genes controlling hair growth and immune response are disrupted in male pattern baldness.

This study analyzed the genetic pathways involved in male androgenetic alopecia (AGA) by examining hair follicles from individuals with AGA. The authors found dysregulation of genes involved in various pathways, including those related to androgen, Wnt/B-cat, TGFB/BMP, and hair follicle formation and differentiation. They also identified upregulation of immune response-related genes in AGA follicles, suggesting that autoimmune hair follicle inflammation may be implicated in AGA.

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Research cited in this study

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research Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

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research Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression

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AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

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Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.

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research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations, June 2013 in “Journal of Investigative Dermatology”

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research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations, November 2010 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

research Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells

70 citations, January 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Androgens slow hair growth by altering Wnt signaling in balding cells.

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Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

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Regulatory Pathways Implicated in Male Androgenetic Alopecia Pathogenesis

Research cited in this study

research Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

research Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression

research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

research Beyond Goosebumps: Does the Arrector Pili Muscle Have a Role in Hair Loss?

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

research Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells

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