Regulatory Pathways Implicated in Male Androgenetic Alopecia Pathogenesis

November 2017 in “ British Journal of Dermatology ”

Elaine G.Y. Chew

androgenetic alopecia AGA androgen Wnt/B-cat TGFB BMP hair follicle formation hair follicle differentiation immune response autoimmune hair follicle inflammation male pattern baldness Wnt signaling pathway TGF-beta bone morphogenetic proteins hair follicle development hair follicle growth immune system response autoimmune inflammation

TLDR Genes controlling hair growth and immune response are disrupted in male pattern baldness.

This study analyzed the genetic pathways involved in male androgenetic alopecia (AGA) by examining hair follicles from individuals with AGA. The authors found dysregulation of genes involved in various pathways, including those related to androgen, Wnt/B-cat, TGFB/BMP, and hair follicle formation and differentiation. They also identified upregulation of immune response-related genes in AGA follicles, suggesting that autoimmune hair follicle inflammation may be implicated in AGA.

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Research cited in this study

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research Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

27 citations , April 2017 in “British Journal of Dermatology”

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74 citations , June 2013 in “Journal of Investigative Dermatology”

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research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations , November 2010 in “Journal of Dermatological Science”

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research Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells

70 citations , January 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

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6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community dunno if it's growing anything but it's making my scalp red

in Technology 182 upvotes 2 years ago

Hair loss and potential treatments, primarily focusing on Finasteride and Minoxidil. Other solutions discussed include PRP, dermarolling, LLP, and scalp tension relief.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Seb derm is eating my hair?!?!

in Chat 41 upvotes 1 year ago

A 22-year-old male is experiencing hair loss due to seborrheic dermatitis, not male pattern baldness, and is seeking advice. Suggestions include using Nizoral, sulfate-free and ketoconazole shampoos, cutting hair short, using cold water, avoiding picking scabs, and trying selenium sulfide shampoo or finasteride.

community Roughly 1.5 years progress. Dut, Fin, Minox, RU.

in Progress Pictures 804 upvotes 3 years ago

A user's progress with treatments for hair loss, including Dutasteride, Finasteride, Minoxidil, and RU. Other members of the conversation provided tips such as using Microneedling and Tretinoin to increase regrowth and wounding areas of the scalp that are thinning in order to fill them in.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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