Regulatory Pathways Implicated in Male Androgenetic Alopecia Pathogenesis

November 2017 in “ British Journal of Dermatology ”

Elaine G.Y. Chew

androgenetic alopecia AGA androgen Wnt/B-cat TGFB BMP hair follicle formation hair follicle differentiation immune response autoimmune hair follicle inflammation male pattern baldness Wnt signaling pathway TGF-beta bone morphogenetic proteins hair follicle development hair follicle growth immune system response autoimmune inflammation

TLDR Genes controlling hair growth and immune response are disrupted in male pattern baldness.

This study analyzed the genetic pathways involved in male androgenetic alopecia (AGA) by examining hair follicles from individuals with AGA. The authors found dysregulation of genes involved in various pathways, including those related to androgen, Wnt/B-cat, TGFB/BMP, and hair follicle formation and differentiation. They also identified upregulation of immune response-related genes in AGA follicles, suggesting that autoimmune hair follicle inflammation may be implicated in AGA.

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