MRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia

    María Isabel Rodríguez-Lara, Cristina Serrano Falcón, Sergio Martínez‐Rodríguez, Juan Antonio Vera Torres, Salvio Serrano, Esperanza Ortega
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    TLDR Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.
    The study examined mRNA levels of aromatase, 5α-Reductase isozymes, and prostate cancer-related genes in plucked hair from 20 young men, half of whom had Androgenic Alopecia (AGA) and half were healthy controls. The results showed that men with AGA had significantly higher 5α-Reductase type 2 (5α-R2) mRNA levels compared to controls. Some men with AGA also had elevated mRNA levels of 5α-Reductase type 1 (5α-R1) or 5α-Reductase type 3 (5α-R3), which may explain varied responses to 5α-R inhibitor treatments. Additionally, 6 out of 84 genes implicated in prostate cancer showed significant changes in the AGA group compared to controls. These findings suggest a potential link between AGA and alterations in gene expression related to prostate cancer, and may contribute to the development of novel therapeutic approaches.
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