The Promotion of Hair Regrowth by Topical Application of a Perilla Frutescens Extract Through Increased Cell Viability and Antagonism of Testosterone and Dihydrotestosterone

    September 2017 in “ Journal of Natural Medicines ”
    Jingjie Li, Zheng Li, Lijuan Gu … Chang‐Keun Sung
    Studysummary This study reported that the n-butanol fraction of Perilla frutescens extract, particularly rosmarinic acid, showed potential for hair regrowth and anti-androgenic activity in male mice, suggesting it as a possible treatment for androgenetic alopecia.
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    Research cited in this study 10

    1. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    2. Weight Gain and Hair Loss During Anti-TNF Therapy International Journal of Rheumatology · 2012
    3. Inhibitory Activities of Puerariae Flos Against Testosterone 5α-Reductase and Its Hair Growth Promotion Activities Journal of Natural Medicines · 2011
    4. Effects of Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair Regrowth in Testosterone-Treated Mice Phytotherapy Research · 2011
    5. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    6. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    7. Effect of 1 mg/Day Finasteride on Concentrations of Serum Prostate-Specific Antigen in Men With Androgenic Alopecia: A Randomized Controlled Trial Lancet Oncology · 2006
    8. The Hair Cycle Journal of Cell Science · 2006
    9. Splenic Eumelanin Differs From Hair Eumelanin in C57BL/6 Mice Acta Biochimica Polonica · 2005
    10. Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2000