Medications Most Commonly Associated With Erectile Dysfunction: Evaluation Of The Food And Drug Administration National Pharmacovigilance Database

July 2022 in “ Sexual Medicine ”

Elie Kaplan-Marans, Arshia Sandozi, Mariela Martinez, Jeffrey E. Lee, Ariel Schulman, Jacob B. Khurgin

5-α reductase inhibitors neuropsychiatric medications finasteride dutasteride 5-ARIs

TLDR Certain medications, especially 5-α reductase inhibitors and neuropsychiatric drugs, are often linked to erectile dysfunction.

The study analyzed the FDA Adverse Event Reporting System (FAERS) from 2010 to 2020 to identify medications most frequently associated with erectile dysfunction (ED). Excluding treatments for ED, the top 20 medications accounted for 6,142 reports of ED, with 5-α reductase inhibitors (5-ARIs) and neuropsychiatric medications making up 46% and 40% of these reports, respectively. Finasteride and dutasteride had the highest Proportional Reporting Ratios (PRRs) of 110.03 and 9.40. The study highlights the need for physicians to be aware of these associations to better counsel patients and improve their quality of life. However, the data does not establish causality and cannot calculate ED incidence rates.

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Medications Most Commonly Associated With Erectile Dysfunction: Evaluation Of The Food And Drug Administration National Pharmacovigilance Database

Research cited in this study

research Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians

research Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

research Enduring Sexual Dysfunction After Treatment With Antidepressants, 5α-Reductase Inhibitors, and Isotretinoin: 300 Cases

research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

research Risk of Erectile Dysfunction Associated with Use of 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia or Alopecia: Population-Based Studies Using the Clinical Practice Research Datalink

research Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis

research 5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis

research Organic Causes of Erectile Dysfunction in Men Under 40

research Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

research Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss

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