Comparative Efficacy of Minoxidil and 5-Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta-Analysis Study of Current Empirical Evidence

    Aditya K. Gupta, Mary A. Bamimore, Greg Williams, Mesbah Talukder
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    TLDR Dutasteride 0.5 mg/day is the most effective treatment for male pattern hair loss.
    This network meta-analysis study evaluated the efficacy of minoxidil, finasteride, and dutasteride monotherapies for male pattern hair loss by analyzing 33 eligible studies. The study assessed changes in hair density and independent observer assessments over 24 and 48 weeks. Dutasteride at 0.5 mg/day was found to be the most effective treatment overall. Among FDA-approved treatments, topical minoxidil 5% was the most effective topical option, while finasteride 1 mg/day was the most effective oral treatment. Dutasteride mesotherapy was significantly less effective than its oral administration.
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