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    Did you mean 5α-reductase inhibitors?
    Glossary 5α-reductase inhibitors

    block enzyme converting testosterone to hair-loss-causing DHT

    5α-reductase inhibitors, also known as 5-ARIs, are medications that block the enzyme 5α-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), a hormone that can contribute to conditions like male pattern baldness and benign prostatic hyperplasia (BPH). By inhibiting this enzyme, 5-ARIs can help reduce hair loss and shrink an enlarged prostate.

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    Research 10 of 1000+

    1. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    2. The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention 2011 · 147 citations
    3. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012 · 124 citations
    4. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017 · 90 citations
    5. 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection The Journal of Sexual Medicine · 2008 · 78 citations
    6. Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation Expert Opinion on Drug Safety · 2012 · 71 citations
    7. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta) Teratology · 1997 · 67 citations
    8. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism · 1994 · 59 citations
    9. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016 · 57 citations
    10. Selective non-steroidal inhibitors of 5α-reductase type 1 2004 · 49 citations
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    Community 10 of 1000+

    1. FCE 28260: A Forgotten 5α-Reductase Inhibitor Community · 22 Aug 2024
    2. Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction Reddit · 15 Jul 2026
    3. BREAKTHROUGH: I’m a radiochemist and discovered a radioactive isotope scalp serum that OUTPERFORMS Minoxidil and 5-AR inhibitors! (Lab Data Inside) Reddit · 10 Jun 2025
    4. Why does this industry still revolve around 5-AR inhibitors? Reddit · 14 Jun 2021
    5. [Discussion] Trichoscopy in sudden-onset AGA: Pathology and reversibility of "Yellow Dots" without 5AR-inhibitors? Reddit · 22 Mar 2026
    6. Guys if you can’t take 5AR inhibitors still get on treatment ASAP Reddit · 6 Jan 2026
    7. 1 year 5-ar. Blood test results Reddit · 29 Jul 2025
    8. Meta analysis of minoxidil only vs 5AR inhibitors Reddit · 16 May 2025
    9. Can gains from stemoxydine be permanently kept with 5AR inhibitors? Reddit · 29 Dec 2024
    10. FINALLY stopped shedding constantly after 1 year on 5ar inhibitors!! Moral of the story: Just wait Reddit · 15 Oct 2024
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    Learn 3 of 24

    1. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Neem Oil Oil from the neem tree, used in traditional remedies
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