Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on Botulinum Toxin for Androgenetic Alopecia

June 2024 in “ Dermatology and therapy ”

Jiaqi Li, Jiaqi Li, Jiaqi Li, Jiaqi Li, Jiaqi Li, Jiaqi Li, Jiaqi Li

intradermal injection intramuscular injection botulinum toxin androgenetic alopecia hair density hair diameter alopecia areata BoNT AGA Botox

From the encyclopedia

Botox →

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study reviewed recent advancements in using botulinum toxin for treating androgenetic alopecia and emphasized the need for further research to determine the most effective injection sites and depths, as current strategies show inconsistent results. Our plain-language summary of this paper — not a Tressless recommendation.

This split-scalp, randomized trial involving 29 patients compared intradermal versus intramuscular botulinum toxin (BoNT) injections for androgenetic alopecia (AGA). Intramuscular injections significantly improved hair density more than intradermal injections (p<0.001), though both methods increased hair diameter similarly (p=0.433). Intradermal injections were more painful (p=0.036), and one case of alopecia areata was reported. The study suggests the need for personalized treatment approaches and further research to optimize BoNT injection protocols for AGA.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

16 / 16 results

Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/Mir-506-3p/Bax Axis

research Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/Mir-506-3p/Bax Axis

January 2024 in “Aesthetic Plastic Surgery”

This study found that botulinum toxin type A inhibited apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.

Assessment of Efficacy of Different Botulinum Toxin A Concentrations in the Treatment of Androgenetic Alopecia Assessed by Dermoscopy

research Assessment of Efficacy of Different Botulinum Toxin A Concentrations in the Treatment of Androgenetic Alopecia Assessed by Dermoscopy

August 2023 in “Journal of Cosmetic Dermatology”

In this study, injecting two different concentrations of botulinum toxin A was found to be safe and effective for treating androgenetic alopecia in Egyptian men and women, with improvements in hair grade and vellus hair density observed over six months.

research Medical and Procedural Treatment of Androgenetic Alopecia – Where Are We?

August 2023 in “Journal of The American Academy of Dermatology”

This source highlights new developments in treating androgenetic alopecia, including low-dose oral minoxidil and advancements in photobiomodulation, platelet-rich plasma, and hair transplantation techniques, providing clinicians with more options.

research Androgenetic Alopecia: Therapy Update

May 2023 in “Drugs”

This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.

research What's New in Therapy for Male Androgenetic Alopecia?

2 citations , September 2022 in “American Journal of Clinical Dermatology”

research A Study of Combination Unilateral Subcutaneous Botulinum Toxin A Treatment for Androgenetic Alopecia

June 2022 in “Journal of Cosmetic Dermatology”

This study found that combining botulinum toxin A injections with finasteride and minoxidil increased hair density in patients with androgenic alopecia more effectively than finasteride and minoxidil alone.

research The Psychological Consequences of Androgenetic Alopecia: A Systematic Review

1 citations , April 2022 in “Journal of Cosmetic Dermatology”

This review highlights that androgenetic alopecia significantly impacts psychological well-being and quality of life, emphasizing the need for integrated psychological support alongside dermatological treatment.

research Efficacy of Botulinum Toxin A Injection in the Treatment of Androgenic Alopecia: A Comparative Controlled Study

3 citations , January 2022 in “Journal of Cosmetic Dermatology”

This study found that for treating androgenetic alopecia, LC hair essence serum injections provided excellent results with fewer side effects compared to botulinum toxin A, which also showed significant efficacy but with higher associated costs and more frequent side effects.

research Is There a Rationale for the Use of Botulinum Toxin in the Treatment of Androgenetic Alopecia?

4 citations , April 2021 in “Journal of Cosmetic Dermatology”

Botulinum toxin may help hair loss by increasing blood flow and reducing harmful factors.

research Reply to: The Effect of Intradermal Botulinum Toxin on Androgenetic Alopecia and Its Possible Mechanism

1 citations , July 2020 in “Journal of The American Academy of Dermatology”

This review discusses the potential mechanisms by which intradermal botulinum toxin may affect androgenetic alopecia but notes that high-evidence clinical trials have yet to show conclusive results.

research Therapeutic Effect of Botulinum Toxin on Scalp Alopecia: Physiopathology and Reported Cases - A Systematic Review

13 citations , May 2020 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

This systematic review found inconclusive evidence on the effectiveness of botulinum toxin for treating alopecia and highlighted the need for further prospective randomized controlled trials.

research The Effect of Intradermal Botulinum Toxin on Androgenetic Alopecia and Its Possible Mechanism

15 citations , April 2020 in “Journal of The American Academy of Dermatology”

In this study, intradermal injection of botulinum toxin was associated with increased hair growth in men with androgenetic alopecia through the suppression of TGF-β1 secretion from dermal papilla cells.

research Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

15 citations , January 2020 in “BioMed Research International”

In this study of patients with androgenetic alopecia, botulinum toxin type A was found to significantly increase hair counts and improve hair density and coverage, with enhanced results observed when combined with oral finasteride, revealing a safe and effective treatment approach without adverse effects.

A Small Dose of Botulinum Toxin A Is Effective for Treating Androgenetic Alopecia in Chinese Patients