MiRNA Microarray Profiling in Patients with Androgenic Alopecia and the Effects of miR-133b on Hair Growth

December 2020 in “ Experimental and Molecular Pathology ”

Wenjia Deng, Ting Hu, Le Han, Ben Liu, Xin Tang, Haiyan Chen, Xianyan Chen, Miaojian Wan

miRNA microarray profiling androgenic alopecia miR-133b hair growth scalp tissues therapeutic target hair loss hair regrowth

Studysummary This study found that patients with androgenetic alopecia exhibit specific miRNA expression profiles, suggesting that abnormal miR-133b expression may inhibit the Wnt/β-catenin pathway and affect hair growth.

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The study conducted miRNA microarray profiling in patients with androgenic alopecia and found that miR-133b was significantly downregulated in affected scalp tissues. Further experiments showed that overexpression of miR-133b promoted hair growth in vitro and in vivo, suggesting that miR-133b may be a potential therapeutic target for androgenic alopecia.

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