Multi-Omics and AI-Driven Advances in miRNA-Mediated Hair Follicle Regulation in Cashmere Goats

July 2025 in “ Frontiers in Veterinary Science ”

Zhang Chun-hua, Le Fu, Shengli Li, Wu Sachula, Bao Hua, Lan Mu, Marco Antonini, Haizhou Sun

TLDR MicroRNAs and AI can improve cashmere goat hair quality and aid in hair disorder diagnosis.

This review examines the role of microRNAs (miRNAs) in hair follicle regulation and development in cashmere goats, emphasizing their impact on fiber traits and potential applications in precision breeding and therapeutic strategies for hair disorders. Key miRNAs such as miR-31, miR-22, and miR-214 are identified for their influence on follicle growth and hair shaft formation. The integration of multi-omics approaches and AI-driven analytics has revealed complex regulatory networks involving miRNAs, offering insights into improving cashmere fiber quality and developing miRNA-based therapies for conditions like alopecia. Despite promising findings, challenges remain in miRNA delivery methods, necessitating further research to enhance in vivo applications.

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