HNG, A Humanin Analogue, Promotes Hair Growth By Inhibiting Anagen-To-Catagen Transition

    June 2020 in “ International Journal of Molecular Sciences ”
    Sung Min Kim, Jung-Il Kang, Hoon-Seok Yoon … Hee‐Kyoung Kang
    Studysummary This study found that the humanin analogue HNG significantly promoted hair growth in vitro and in vivo by prolonging the anagen phase and inhibiting hair follicle cell apoptosis in mice.
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    Research cited in this study 26

    1. Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways Biological & Pharmaceutical Bulletin · 2018
    2. A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth Experimental Dermatology · 2018
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    6. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    7. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    8. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    9. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    10. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    11. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    12. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    13. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
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    16. Hair Cycle-Specific Expression of Versican in Human Hair Follicles Journal of Dermatological Science · 2005
    17. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor Alpha Is Checked by ER Beta Signaling Endocrinology · 2005
    18. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    19. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    20. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    21. The Chemotactic Effect of a Dermal Papilla Cell-Derived Factor on Outer Root Sheath Cells Journal of Dermatological Science · 2001
    22. Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2000
    23. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    24. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996
    25. Transfection of Rat Dermal Papilla Cells with a Gene Encoding a Temperature-Sensitive Polyomavirus Large T Antigen Generates Cell Lines Retaining a Differentiated Phenotype Journal of Cell Science · 1994
    26. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990

    Related research 6

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    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    6. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000