HNG, A Humanin Analogue, Promotes Hair Growth By Inhibiting Anagen-To-Catagen Transition

June 2020 in “ International Journal of Molecular Sciences ”

Sung Min Kim, Jung-Il Kang, Hoon-Seok Yoon, Youn Kyung Choi, Ji Soo Go, Sun Kyung Oh, Meejung Ahn, Jeongtae Kim, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee‐Kyoung Kang

HNG humanin analogue anagen phase catagen phase dermal papilla cells Erk1/2 Akt Stat3 VEGF hair follicle cells

TLDR HNG helps hair grow by keeping hair in the growth phase longer.

The study found that HNG, a humanin analogue, promoted hair growth by inhibiting the transition from the anagen (growth) phase to the catagen (regression) phase, thereby prolonging the anagen duration. HNG increased dermal papilla cell (DPC) proliferation and hair shaft elongation in vitro and ex vivo, and extended the anagen phase in vivo by activating Erk1/2, Akt, and Stat3 signaling pathways and up-regulating vascular endothelial growth factor (VEGF) levels. These effects were similar to those of minoxidil, suggesting HNG's potential as a treatment for alopecia. However, further studies were needed to explore its clinical benefits.

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