HNG, A Humanin Analogue, Promotes Hair Growth By Inhibiting Anagen-To-Catagen Transition

June 2020 in “ International Journal of Molecular Sciences ”

Sung Min Kim, Jung-Il Kang, Hoon-Seok Yoon, Youn Kyung Choi, Ji Soo Go, Sun Kyung Oh, Meejung Ahn, Jeongtae Kim, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee‐Kyoung Kang

HNG humanin analogue anagen phase catagen phase dermal papilla cells Erk1/2 Akt Stat3 VEGF hair follicle cells

TLDR HNG helps hair grow by keeping hair in the growth phase longer.

The study investigated the effects of HNG, a humanin analogue, on hair growth, focusing on its ability to prolong the anagen phase and inhibit the transition to the catagen phase in mice. HNG was found to significantly increase dermal papilla cell proliferation and hair shaft elongation. It activated signaling pathways such as Erk1/2, Akt, and Stat3, and up-regulated VEGF levels, which are crucial for maintaining the anagen phase. These findings suggested that HNG could promote hair growth by extending the anagen phase and preventing apoptosis in hair follicle cells.

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