Melatonin Promotes the Proliferation of Dermal Papilla Cells in Cashmere Goats via Activation of Chi-let-7d-5p/WNT2 Axis

November 2024 in “ Genomics ”

Junyang Liu, Lei Zhu, Qing Mu, Jiasen Liu, Yunhua Li, Wendian Gong, Tergel Chahaer, Yukun Song, Erhan Hai, Sheng Wang, Yanjun Zhang, Zhao Yanhong

melatonin dermal papilla cells chi-let-7d-5p WNT2 hair follicles miRNAs secondary hair follicles

TLDR Melatonin boosts hair growth in cashmere goats by helping certain cells multiply.

This study investigates how melatonin influences hair growth in cashmere goats by promoting the proliferation of dermal papilla cells (DPCs) through the chi-let-7d-5p/WNT2 axis. Melatonin, which is regulated by environmental factors like light, enhances cashmere production by increasing the density of secondary hair follicles. The research identified 170 differentially expressed miRNAs during melatonin-induced hair follicle growth, with chi-let-7d-5p being a key miRNA that negatively regulates WNT2 expression. The findings suggest that melatonin down-regulates chi-let-7d-5p, thereby promoting WNT2 expression and DPC proliferation, elucidating a molecular mechanism for melatonin's role in hair follicle development.

View this study on sciencedirect.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 259 results

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Does melatonin dissolve in isopropyl alcohol

in Technology 7 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community Hair loss causes are still a myth.

in Chat 16 upvotes 3 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase

in Research/Science 132 upvotes 3 years ago

Hair loss therapies focusing on hair follicle sugar metabolism and aldose reductase. Potential treatments include magnesium supplements, avoiding high glycemic index foods, and antioxidants.

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

in Research/Science 8 upvotes 2 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

community Has anyone ever had success with just micro-needling?

in Microneedling 20 upvotes 8 months ago

People are discussing if microneedling alone can improve hair loss without using treatments like minoxidil, finasteride, or RU58841. Some users report moderate success with microneedling and natural remedies, but most suggest that results are better when combined with medical treatments.

Related Research

2 / 2 results

research Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

2 citations, February 2022 in “Genomics”

Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

42 citations, September 2015 in “Gene”

FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.