Melatonin Promotes the Proliferation of Dermal Papilla Cells in Cashmere Goats via Activation of Chi-let-7d-5p/WNT2 Axis

November 2024 in “ Genomics ”

Junyang Liu, Lei Zhu, Qing Mu, Jiasen Liu, Yunhua Li, Wendian Gong, Tergel Chahaer, Yukun Song, Erhan Hai, Sheng Wang, Yanjun Zhang, Zhao Yanhong

melatonin dermal papilla cells chi-let-7d-5p WNT2 hair follicles miRNAs secondary hair follicles

🚨 The study is relevant to hair biology and potentially to human hair growth mechanisms, but it focuses on cashmere goats, which limits direct applicability to human hair loss treatments.

TLDR Melatonin boosts hair growth in cashmere goats by helping certain cells multiply.

This study investigates how melatonin influences hair growth in cashmere goats by promoting the proliferation of dermal papilla cells (DPCs) through the chi-let-7d-5p/WNT2 axis. Melatonin, which is regulated by environmental factors like light, enhances cashmere production by increasing the density of secondary hair follicles. The research identified 170 differentially expressed miRNAs during melatonin-induced hair follicle growth, with chi-let-7d-5p being a key miRNA that negatively regulates WNT2 expression. The findings suggest that melatonin down-regulates chi-let-7d-5p, thereby promoting WNT2 expression and DPC proliferation, elucidating a molecular mechanism for melatonin's role in hair follicle development.

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