Current Insight Into the Functions of MicroRNAs in Common Human Hair Loss Disorders: A Mini Review

April 2021 in “ Human Cell ”

Sujay Paul, Iván Licona-Vázquez, Francisco I. Serrano‐Cano, Natalia Frías-Reid, Carolina Pacheco-Dorantes, Surajit Pathak, Samik Chakraborty, Aashish Srivastava

TLDR MicroRNAs may help diagnose and treat hair loss disorders.

This mini review explored the role of microRNAs (miRNAs) in common human hair loss disorders, emphasizing their regulatory functions in hair follicle development and cycling. It highlighted the involvement of miRNAs in the pathophysiology of conditions like androgenetic alopecia, alopecia areata, frontal fibrosing alopecia, and female pattern hair loss by affecting gene expression and immune pathways. Specific miRNAs, such as miR-92a-1-5p, miR-328-3p, miR-30b/d, miR-18a-5p, and miR-223, were identified as being associated with these disorders. The review underscored the potential of miRNAs as therapeutic targets and biomarkers for diagnosing and treating hair loss disorders.

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Research cited in this study

23 / 23 results

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Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options

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4 citations , January 2019 in “Annals of Dermatology”

Higher levels of MiR-92a-1-5p and miR-328-3p found in female hair loss patients.

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Certain microRNAs might help identify and understand Frontal Fibrosing Alopecia.

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Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

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