Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients

November 2020 in “ Journal of Dermatological Science ”

Parvaneh Mohammadi, Mohammad Ali Nilforoushzadeh, Khalil Kass Youssef, Ali Sharifi-Zarchi, Sharif Moradi, Pardis Khosravani, Raheleh Aghdami, Payam Taheri, Ghasem Hosseini Salekdeh, Hossein Baharvand, Nasser Aghdami

microRNA hair follicular stem cells progenitor cells androgenic alopecia miR-324-3p hair follicle size reduction differentiation hair loss hair stem cells hair progenitor cells male pattern baldness

TLDR Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.

This study identified microRNA signatures in hair follicular stem and progenitor cells of healthy individuals and those with androgenic alopecia. The study found significant differences in microRNA expression between the two groups, suggesting potential targets for future treatments of this condition. The researchers identified miR-324-3p as a potential treatment target for androgenic alopecia by affecting hair follicle size reduction and differentiation.

View this study on linkinghub.elsevier.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

12 citations, June 2017 in “Cell Cycle”

Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations, April 2016 in “Journal of Investigative Dermatology”

New genes found linked to balding, may help develop future treatments.

research TR3 Is Preferentially Expressed by Bulge Epithelial Stem Cells in Human Hair Follicles

7 citations, January 2016 in “Laboratory Investigation”

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

52 citations, May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

11 citations, January 2015 in “Journal of cellular physiology”

HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

research MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway

103 citations, November 2014 in “Journal of Cell Biology”

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

research An Overview of Alopecias

53 citations, March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

149 citations, June 2010 in “The FASEB journal”

miR-31 regulates hair growth by controlling gene expression in hair follicles.

research Male Androgenetic Alopecia

100 citations, April 2010 in “Expert Opinion on Pharmacotherapy”

Hair loss in men treated best with early medication or transplant, new treatments researched.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations, December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

Similar Research

5 / 909 results

research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives

June 2024 in “Computational and Structural Biotechnology Journal”

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

research The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

2 citations, January 2023 in “International Journal of Biological Sciences”

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

research Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis

3 citations, April 2022 in “Biomolecules”

Higher miR-34a levels and the A variant of the MIR-34A gene are linked to increased risk and severity of alopecia areata.

Revealing Novel Insights on How Oral Supplementation With Collagen Peptides May Prevent Hair Loss: Lessons From the Human Hair Follicle Organ Culture

research Revealing Novel Insights on How Oral Supplementation With Collagen Peptides May Prevent Hair Loss: Lessons From the Human Hair Follicle Organ Culture

March 2024 in “Journal of functional foods”

Collagen peptides from marine and bovine sources may help prevent hair loss by affecting hair follicle stem cells differently.

research Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

1 citations, July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.