Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications

March 2026 in “ Dermatology and Therapy ”

Jesús Gay-Mimbrera, Macarena Aguilar-Luque, Pedro J Gómez-Arias, I Rivera-Ruiz, Francisco J. García, M. Juan-Cencerrado, Carmen Mochón-Jiménez, Esmeralda Parra-Peralbo, Ricardo RUİZ-VİLLAVERDE, José Liñares-Blanco, P. Carmona-Sáez, Beatriz Isla-Tejera, J. Ruano

Alopecia Areata microRNA miRNA immune pathways

TLDR Distinct miRNA signatures could help diagnose and treat severe Alopecia Areata.

The study investigates plasma miRNA profiles in severe Alopecia Areata (AA), revealing distinct signatures that could aid in diagnosis and therapy. Machine learning confirmed the predictive accuracy of these miRNA profiles, while pathway analysis emphasized significant immune pathways involved in AA. The results are exploratory and suggest potential hypotheses, but further functional validation of the candidate miRNAs is necessary.

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Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications

Research cited in this study

research Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey

research European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

research Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database

research Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials

research miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation

research Identification of Differentially Expressed miRNAs in Alopecia Areata That Target Immune-Regulatory Pathways

research SALT II: A New Take on the Severity of Alopecia Tool for Determining Percentage Scalp Hair Loss

research Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment

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